170. Yousefian-Jazi, A., Kim, S., Chu, J. et al. Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice. Molecular Neurodegeneration. 2025 Feb 20(16). 

169. Kim JH, Jeong HG, Hyeon SJ, Park U, Oh WJ, Hwang J, Lim HH, Ko PW, Lee HW, Lee HW, Ryu H, Suk K. Crosstalk between lipocalin-2 and IL-6 in traumatic brain injury: Closely related biomarkers. Experimental neurology. 2024 Dec 115092.

168. Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathologica. 2024 Sep 148(1), 1-19.

167. Kim, S., Chun, H., Kim, Y., Kim, Y., Park, U., Chu, J., ... & Ryu, H. Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease. Molecular Neurodegeneration. 2024 Jul 19(1), 55.

166. Kim, D., Ko, H. Y., Chung, J. I., Park, Y. M., Lee, S., Kim, S. Y., ... & Yun, M. Visualizing cancer-originating acetate uptake through monocarboxylate transporter 1 in reactive astrocytes in the glioblastoma tumor microenvironment. Neuro-Oncology. 2024 May 26(5), 843-857.

165. Kim DK, Choi H, Lee W, Choi H, Hong SB, Jeong JH, Han J, Han JW, Ryu H, Kim JI, Mook-Jung I. Brain hypothyroidism silences the immune response of microglia in Alzheimer's disease animal model. Sci Adv. 2024 Mar 15;10(11).

164. Bhusal A, Kim JH, Kim SC, Hwang EM, Ryu H, Ali MS, Park SC, Lee WH, Suk K. The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes. Cell Rep. 2024 Feb 22;43(3):113813.

163. Kang YJ, Hyeon SJ, McQuade A, Lim J, Baek SH, Diep YN, Do KV, Jeon Y, Jo DG, Lee CJ, Blurton-Jones M, Ryu H, Cho H. Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease. Adv Sci (Weinh). 2024 Mar.

162. Lim S, Shin S, Sung Y, Lee HE, Kim KH, Song JY, Lee GH, Aziz H, Lukianenko N, Kang DM, Boesen N, Jeong H, Abdildinova A, Lee J, Yu BY, Lim SM, Lee JS, Ryu H, Pae AN, Kim YK. Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice. Exp Mol Med. 2023 Mar;55(3):612-627.

161. Kim JH, Kang RJ, Hyeon SJ, Ryu H, Joo H, Bu Y, Kim JH, Suk K. Lipocalin-2 Is a Key Regulator of Neuroinflammation in Secondary Traumatic and Ischemic Brain Injury. Neurotherapeutics. 2023 Apr;20(3):803-821. 

160. Afridi, R., Bhusal, A., Tsuda, M., Ryu, H., & Suk, K. Function of Glial Cells in Neuroinflammatory and Neuroimmunological Responses II. Cells. 2023 Jun;12(13), 1750.

159. Nam MH, Ko HY, Kim D, Lee S, Park YM, Hyeon SJ, Won W, Chung JI, Kim SY, Jo HH, Oh KT, Han YE, Lee GH, Ju YH, Lee H, Kim H, Heo J, Bhalla M, Kim KJ, Kwon J, Stein TD, Kong M, Lee H, Lee SE, Oh SJ, Chun JH, Park MA, Park KD, Ryu H, Yun M, Lee CJ. Visualizing reactive astrocyte-neuron interaction in Alzheimer's disease using 11C-acetate and 18F-FDG. Brain. 2023 Jul 3;146(7):2957-2974. 

158. Jung JW, Kim H, Park J, Woo J, Jeon E, Lee G, Park M, Kim S, Seo H, Cheon S, Dan K, Lee J, Ryu H, Han D. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling. Sci Rep. 2023 Sep 14;13(1):15261. 

157. Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. Correction: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. Mol Psychiatry. 2023 Oct 2;28(10), 4474-4484. 

156. Yoon, Y., Gong, S. C., Kim, M. Y., Baik, S. K., Hong, J. E., Rhee, K. J., ... & Eom, Y. W. Generation of fibrotic liver organoids using hepatocytes, primary liver sinusoidal endothelial cells, hepatic stellate cells, and macrophages. Cells. 2023 Oct;12(21), 2514.

155. Kim D, Ko HY, Chung JI, Park YM, Lee S, Kim SY, Kim J, Chun JH, Han KS, Lee M, Ju YH, Park SJ, Park KD, Nam MH, Kim SH, Shim JK, Park Y, Lim H, Park J, Kim H, Kim S, Park U, Ryu H, Lee SY, Park S, Kang SG, Chang JH, Lee CJ, Yun M. Visualizing Cancer-Originating Acetate Uptake Through MCT1 in Reactive Astrocytes in the Glioblastoma Tumor Microenvironment. Neuro Oncol. 2023 Dec 12;26(5), 843-857.

154. Lee S, Kim TK, Choi JE, Choi Y, You M, Ryu J, Chun YL, Ham S, Hyeon SJ, Ryu H, Kim HS, Im HI. Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease. Theranostics. 2022 Jan 1;12(3):1404-1418.

153. Afridi R, Tsuda M, Ryu H, Suk K. The Function of Glial Cells in the Neuroinflammatory and Neuroimmunological Responses. Cells. 2022 Feb 14;11(4):659. 

152. Kim JH, Kwon O, Bhusal A, Lee J, Hwang EM, Ryu H, Park JY, Suk K. Neuroinflammation Induced by Transgenic Expression of Lipocalin-2 in Astrocytes. Front Cell Neurosci. 2022 Feb 23;16:839118. 

151. Kim H, Kim H, Nguyen LT, Ha T, Lim S, Kim K, Kim SH, Han K, Hyeon SJ, Ryu H, Park YS, Kim SH, Kim IB, Hong GS, Lee SE, Choi Y, Cohen LB, Oh U. Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction. Prog Neurobiol. 2022 Dec;219:102369. 

150. Chang B, Byun J, Kim KK, Lee SE, Lee B, Kim KS, Ryu H, Shin HS, Cheong E. Deletion of Phospholipase C β1 in the Thalamic Reticular Nucleus Induces Absence Seizures. Exp Neurobiol. 2022 Apr 30;31(2):116-130.

149. Yoon Y, Kim S, Seol Y, Im H, Park U, Han HB, Choi JH, Ryu H. Increases of Phosphorylated Tau (Ser202/Thr205) in the Olfactory Regions Are Associated with Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice. Biomedicines. 2022 Apr 7;10(4):865. 

148. Koh W, Park M, Chun YE, Lee J, Shim HS, Park MG, Kim S, Sa M, Joo J, Kang H, Oh SJ, Woo J, Chun H, Lee SE, Hong J, Feng J, Li Y, Ryu H, Cho J, Lee CJ. Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus. Biol Psychiatry. 2022 Apr 15;91(8):740-752.

147. Lee J, Kim S, Kim YH, Park U, Lee J, McKee AC, Kim KH, Ryu H, Lee J. Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy. Biomedicines. 2022 Jul 15;10(7):1718.

146. Latif S, Choi SH, Gyawali A, Hyeon SJ, Kang YS, Ryu H. Antioxidant and Neuroprotective Effects of Paeonol against Oxidative Stress and Altered Carrier-Mediated Transport System on NSC-34 Cell Lines. Antioxidants (Basel). 2022 Jul 18;11(7):1392. 

145. Ju YH, Bhalla M, Hyeon SJ, Oh JE, Yoo S, Chae U, Kwon J, Koh W, Lim J, Park YM, Lee J, Cho IJ, Lee H, Ryu H, Lee CJ. Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer's disease. Cell Metab. 2022 Aug 2;34(8):1104-1120.e8.

144. Lee HN, Hyeon SJ, Kim H, Sim KM, Kim Y, Ju J, Lee J, Wang Y, Ryu H, Seong J. Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington's disease. Acta Neuropathol. 2022 Sep;144(3):521-536. 

143. Kim DK, Jeong H, Bae J, Cha MY, Kang M, Shin D, Ha S, Hyeon SJ, Kim H, Suh K, Choi MS, Ryu H, Yu SW, Kim JI, Kim YS, Lee SW, Hwang D, Mook-Jung I. Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation. Exp Mol Med. 2022 Sep;54(9):1461-1471.

142. Lee S, Shim HS, Park HJ, Chang Y, Han YE, Oh SJ, Lee W, Im H, Seol Y, Ryu H, Kang H, Lee YK, Park S, Yoo J. Elongated nanoporous Au networks improve somatic cell direct conversion into induced dopaminergic neurons for Parkinson's disease therapy. Acta Biomater. 2022 Oct 1;151:561-575. 

141. Kim JH, Afridi R, Cho E, Yoon JH, Lim YH, Lee HW, Ryu H, Suk K. Soluble ANPEP Released From Human Astrocytes as a Positive Regulator of Microglial Activation and Neuroinflammation: Brain Renin-Angiotensin System in Astrocyte-Microglia Crosstalk. Mol Cell Proteomics. 2022 Nov;21(11):100424. 

140. Gyawali A, Latif S, Choi SH, Hyeon SJ, Ryu H, Kang YS. Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis. J Biomed Sci. 2022 Jan 10;29(1):2. 

139. Choi SH, Yousefian-Jazi A, Hyeon SJ, Nguyen PTT, Chu J, Kim S, Kim S, Ryu HL, Kowall NW, Ryu H, Lee J. Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS. J Biomed Sci. 2022 Dec 20;29(1):106. 

138. Hyeon, S.J., Park, J., Yoo, J., Kim, S.H., Hwang, Y.J., Kim, S.C., Liu, T., Shim, H.S., Kim, Y., Cho, Y. and Woo, J., 2021. Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington’s disease. Progress in Neurobiology, p.102110.

137. Elbatrawy, A.A., Hyeon, S.J., Yue, N., Osman, E.E.A., Choi, S.H., Lim, S., Kim, Y.K., Ryu, H., Cui, M. and Nam, G., 2021. “Turn-On” Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer’s Disease: Rational Design, Synthesis, and Molecular Docking. ACS sensors.

136. Subramanian, M., Hyeon, S.J., Das, T., Suh, Y.S., Kim, Y.K., Lee, J.S., Song, E.J., Ryu, H. and Yu, K., 2021. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nature communications, 12(1), pp.1-15.

135. Gyawali, A., Hyeon, S.J., Ryu, H. and Kang, Y.S., 2021. The Alteration of L-Carnitine Transport and Pretreatment Effect under Glutamate Cytotoxicity on Motor Neuron-Like NSC-34 Lines. Pharmaceutics, 13(4), p.551.

134. Kim, J.H., Jung, H.G., Kim, A., Shim, H.S., Hyeon, S.J., Lee, Y.S., Han, J., Jung, J.H., Lee, J., Ryu, H. and Park, J.Y., 2021. Hevin–calcyon interaction promotes synaptic reorganization after brain injury. Cell Death & Differentiation, pp.1-18.

133. Woo, J., Cho, H., Seol, Y., Kim, S.H., Park, C., Yousefian-Jazi, A., Hyeon, S.J., Lee, J. and Ryu, H., 2021. Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants, 10(2), p.229.

132. Kim, J.H., Afridi, R., Han, J., Jung, H.G., Kim, S.C., Hwang, E.M., Shim, H.S., Ryu, H., Choe, Y., Hoe, H.S. and Suk, K., 2021. Gamma subunit of complement component 8 is a neuroinflammation inhibitor. Brain, 144(2), pp.528-552.

131. Gyawali, A., Gautam, S., Hyeon, S.J., Ryu, H. and Kang, Y.S., 2021. L-Citrulline level and transporter activity are altered in experimental models of amyotrophic lateral sclerosis. Molecular Neurobiology, 58(2), pp.647-657.

130. Han, Y.M., Kim, M.S., Jo, J., Shin, D., Kwon, S.H., Seo, J.B., Kang, D., Lee, B.D., Ryu, H., Hwang, E.M. and Kim, J.M., 2021. Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior. Molecular psychiatry, pp.1-10.

129. Kim, C., Yousefian-Jazi, A., Choi, S.H., Chang, I., Lee, J. and Ryu, H., 2021. Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease. International Journal of Molecular Sciences, 22(22), p.12499.

128. Hwang, Y.J., Hyeon, S.J., Kim, Y., Lim, S., Lee, M.Y., Kim, J., Londhe, A.M., Gotina, L., Kim, Y., Pae, A.N. and Cho, Y.S., 2021. Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model. Journal of enzyme inhibition and medicinal chemistry, 36(1), pp.856-868.

127. Yousefian-Jazi, A., Seol, Y., Kim, J., Ryu, H.L., Lee, J. and Ryu, H., 2020. Pathogenic genome signatures that damage motor neurons in amyotrophic lateral sclerosis. Cells, 9(12), p.2687.

126. Chun, H., Im, H., Kang, Y.J., Kim, Y., Shin, J.H., Won, W., Lim, J., Ju, Y., Park, Y.M., Kim, S. and Lee, S.E., 2020. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H 2 O 2− production. Nature Neuroscience, 23(12), pp.1555-1566.

125. Seol, Y., Ki, S., Ryu, H.L., Chung, S., Lee, J. and Ryu, H., 2020. How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD. Frontiers in Molecular Neuroscience, 13, p.214.

124. Cho, H., Hyeon, S.J., Shin, J.Y., Alvarez, V.E., Stein, T.D., Lee, J., Kowall, N.W., McKee, A.C., Ryu, H. and Seo, J.S., 2020. Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders. Scientific reports, 10(1), pp.1-12.

123. Lee, M.Y., Lee, J., Hyeon, S.J., Cho, H., Hwang, Y.J., Shin, J.Y., McKee, A.C., Kowall, N.W., Kim, J.I., Stein, T.D. and Hwang, D., 2020. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease. Aging cell, 19(6), p.e13153.

122. Choi, J.W., Ju, Y.H., Choi, Y., Hyeon, S.J., Gadhe, C.G., Park, J.H., Kim, M.S., Baek, S., Kim, Y., Park, K.D. and Pae, A.N., 2020. PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates. ACS Chemical Neuroscience, 11(12), pp.1801-1810.

121. Cap, K.C., Jung, Y.J., Choi, B.Y., Hyeon, S.J., Kim, J.G., Min, J.K., Islam, R., Hossain, A.J., Chung, W.S., Suh, S.W. and Ryu, H., 2020. Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations. Redox biology, 32, p.101446.

120. Shin, S., Kim, D., Song, J.Y., Jeong, H., Hyeon, S.J., Kowall, N.W., Ryu, H., Pae, A.N., Lim, S. and Kim, Y.K., 2020. Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy. Progress in neurobiology, 187, p.101782.

119. Yoo, J., Kim, J., Lee, J.H., Kim, H., Jang, S.J., Seo, H.H., Oh, S.T., Hyeon, S.J., Ryu, H., Kim, J. and Moh, S.H., 2020. Acceleration of somatic cell reprogramming into the induced pluripotent stem cell using a mycosporine-like amino acid, Porphyra 334. Scientific reports, 10(1), pp.1-10.

118. Friedberg, J.S., Aytan, N., Cherry, J.D., Xia, W., Standring, O.J., Alvarez, V.E., Nicks, R., Svirsky, S., Meng, G., Jun, G. and Ryu, H., 2020. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype. Scientific reports, 10(1), pp.1-10.

117. Heo, J.Y., Nam, M.H., Yoon, H.H., Kim, J., Hwang, Y.J., Won, W., Woo, D.H., Lee, J.A., Park, H.J., Jo, S. and Lee, M.J., 2020. Aberrant tonic inhibition of dopaminergic neuronal activity causes motor symptoms in animal models of Parkinson’s disease. Current Biology, 30(2), pp.276-291.

116. Lee, H.N., Sim, K.M., Kim, H., Ju, J., Pae, A.N., Park, J.B., Ryu, H. and Seong, J., 2019. Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism. Scientific reports, 9(1), pp.1-12.

115. Lee, J., Nguyen, P.T., Shim, H.S., Hyeon, S.J., Im, H., Choi, M.H., Chung, S., Kowall, N.W., Lee, S.B. and Ryu, H., 2019. EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(7), pp.1938-1945.

114. Bi, B., Choi, H.P., Hyeon, S.J., Sun, S., Su, N., Liu, Y., Lee, J., Kowall, N.W., McKee, A.C., Yang, J.H. and Ryu, H., 2019. Quantitative proteomic analysis reveals impaired axonal guidance signaling in human postmortem brain tissues of chronic traumatic encephalopathy. Experimental neurobiology, 28(3), p.362.

113. Kim, Y.H., Shim, H.S., Kim, K.H., Lee, J., Chung, B.C., Kowall, N.W., Ryu, H. and Lee, J., 2019. Metabolomic analysis identifies alterations of amino acid metabolome signatures in the postmortem brain of Alzheimer's disease. Experimental neurobiology, 28(3), p.376.

112. Chen, S., Yu, C., Rong, L., Li, C.H., Qin, X., Ryu, H. and Park, H., 2018. Altered synaptic vesicle release and Ca2+ influx at single presynaptic terminals of cortical neurons in a knock-in mouse model of Huntington’s disease. Frontiers in molecular neuroscience, 11, p.478.

111. Bae, Y.H., Joo, H., Bae, J., Hyeon, S.J., Her, S., Ko, E., Choi, H.G., Ryu, H., Hur, E.M., Bu, Y. and Lee, B.D., 2018. Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell death & disease, 9(11), pp.1-19.

110. Chun, H., An, H., Lim, J., Woo, J., Lee, J., Ryu, H. and Lee, C.J., 2018. Astrocytic proBDNF and tonic GABA distinguish active versus reactive astrocytes in hippocampus. Experimental neurobiology, 27(3), p.155.

109. Kim, M.H., Shim, H., Bae, K.S., Ryu, H. and Jang, J.Y., 2018. Risk Factors Associated with Mortality of Patients with Pelvic Fractures and Hemodynamic Instability in a Korean Trauma Center. Journal of Acute Care Surgery, 8(1), pp.19-24.

108. Lee, J.Y., Han, S.H., Park, M.H., Baek, B., Song, I.S., Choi, M.K., Takuwa, Y., Ryu, H., Kim, S.H., He, X. and Schuchman, E.H., 2018. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease. Nature communications, 9(1), pp.1-14.

107. Yoon, Y., Park, H., Kim, S., Nguyen, P.T., Hyeon, S.J., Chung, S., Im, H., Lee, J., Lee, S.B. and Ryu, H., 2018. Genetic ablation of EWS RNA binding protein 1 (EWSR1) leads to neuroanatomical changes and motor dysfunction in mice. Experimental neurobiology, 27(2), p.103.

106.  Lee, J., Kim, Y., Liu, T., Hwang, Y.J., Hyeon, S.J., Im, H., Lee, K., Alvarez, V.E., McKee, A.C., Um, S.J. and Hur, M., 2018. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging cell, 17(1), p.e12679.

105. Jung, D., Hwang, Y.J., Ryu, H., Kano, M., Sakimura, K. and Cho, J., 2016. Conditional knockout of Cav2. 1 disrupts the accuracy of spatial recognition of CA1 place cells and Spatial/Contextual recognition behavior. Frontiers in behavioral neuroscience, 10, p.214.

104. Li, C., Choi, H.P., Wang, X., Wu, F., Chen, X., Lü, X., Jing, R., Ryu, H., Wang, X., Azadzoi, K.M. and Yang, J.H., 2017. Post-translational modification of human histone by wide tolerance of acetylation. Cells, 6(4), p.34.

103. Choi, H., Kim, H.J., Kim, J., Kim, S., Yang, J., Lee, W., Park, Y., Hyeon, S.J., Lee, D.S., Ryu, H. and Chung, J., 2017. Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport. Molecular neurodegeneration, 12(1), pp.1-14.

102. Lee, J., Hwang, Y.J., Kim, Y., Lee, M.Y., Hyeon, S.J., Lee, S., Kim, D.H., Jang, S.J., Im, H., Min, S.J. and Choo, H., 2017. Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington’s disease. Acta neuropathologica, 134(5), pp.729-748.

101. Park, K.S., Kim, M.K., Seo, Y., Ha, T., Yoo, K., Hyeon, S.J., Hwang, Y.J., Lee, J., Ryu, H., Choo, H. and Chong, Y., 2017. A difluoroboron β-diketonate probe shows “turn-on” near-infrared fluorescence specific for tau fibrils. ACS chemical neuroscience, 8(10), pp.2124-2131.

100. Park, I., Hwang, Y.J., Kim, T., Viswanath, A.N.I., Londhe, A.M., Jung, S.Y., Sim, K.M., Min, S.J., Lee, J.E., Seong, J., Kim, Y.K., No, K.T., Ryu, H. and Pae A.N., 2017. In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level. Journal of computer-aided molecular design, 31(10), pp.877-889.

99. Seo, J.S., Lee, S., Shin, J.Y., Hwang, Y.J., Cho, H., Yoo, S.K., Kim, Y., Lim, S., Kim, Y.K., Hwang, E.M. and Kim, S.H., 2017. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Experimental & molecular medicine, 49(5), pp.e333-e333.

98. Lee, N.Y., Kim, Y., Ryu, H. and Kang, Y.S., 2017. The alteration of serine transporter activity in a cell line model of amyotrophic lateral sclerosis (ALS). Biochemical and biophysical research communications, 483(1), pp.135-141.

97. Seo, Y., Park, K.S., Ha, T., Kim, M.K., Hwang, Y.J., Lee, J., Ryu, H., Choo, H. and Chong, Y., 2016. A smart near-infrared fluorescence probe for selective detection of tau fibrils in Alzheimer’s disease. ACS chemical neuroscience, 7(11), pp.1474-1481.

96. Jung, D., Hwang, Y.J., Ryu, H., Kano, M., Sakimura, K. and Cho, J., 2016. Conditional knockout of Cav2. 1 disrupts the accuracy of spatial recognition of CA1 place cells and Spatial/Contextual recognition behavior. Frontiers in behavioral neuroscience, 10, p.214.

95. Lee, J., Hyeon, S.J., Im, H., Ryu, H., Kim, Y. and Ryu, H., 2016. Astrocytes and microglia as non-cell autonomous players in the pathogenesis of ALS. Experimental neurobiology, 25(5), p.233.

94. Lee, C.J., Ahn, H., Lee, S.B., Shin, J.Y., Park, W.Y., Kim, J.I., Lee, J., Ryu, H. and Kim, S., 2016. Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice. BMC medical genomics, 9(1), pp.59-68.

93. Jung, E.S., Choi, H., Song, H., Hwang, Y.J., Kim, A., Ryu, H. and Mook-Jung, I., 2016. p53-dependent SIRT6 expression protects Aβ42-induced DNA damage. Scientific reports, 6(1), pp.1-11.

92. Kim, D., Jeon, J., Cheong, E., Kim, D.J., Ryu, H., Seo, H. and Kim, Y.K., 2016. Neuroanatomical visualization of the impaired striatal connectivity in Huntington’s disease mouse model. Molecular neurobiology, 53(4), pp.2276-2286.

91. Son, S.M., Nam, D.W., Cha, M.Y., Kim, K.H., Byun, J., Ryu, H. and Mook-Jung, I., 2015. Thrombospondin-1 prevents amyloid beta–mediated synaptic pathology in Alzheimer's disease. Neurobiology of aging, 36(12), pp.3214-3227.

90. Hong, C., Seo, H., Kwak, M., Jeon, J., Jang, J., Jeong, E.M., Myeong, J., Hwang, Y.J., Ha, K., Kang, M.J. and Lee, K.P., 2015. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease. Brain, 138(10), pp.3030-3047.

89. Kim, Y., Lee, J. and Ryu, H., 2015. Modulation of autophagy by miRNAs. BMB reports, 48(7), p.371.

88. Byun, J., Son, S.M., Cha, M.Y., Shong, M., Hwang, Y.J., Kim, Y., Ryu, H., Moon, M., Kim, K.S. and Mook-Jung, I., 2015. CR6-interacting factor 1 is a key regulator in A β-induced mitochondrial disruption and pathogenesis of Alzheimer’s disease. Cell Death & Differentiation, 22(6), pp.959-973.

87. Kim, Y., Kang, Y.S., Lee, N.Y., Kim, K.Y., Hwang, Y.J., Kim, H.W., Rhyu, I.J., Her, S., Jung, M.K., Kim, S. and Lee, C.J., 2015. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy, 11(5), pp.796-811.

86. Ha, C.M., Park, D., Kim, Y., Na, M., Panda, S., Won, S., Kim, H., Ryu, H., Park, Z.Y., Rasenick, M.M. and Chang, S., 2015. SNX14 is a bifunctional negative regulator for neuronal 5‐HT6 receptor signaling. Journal of cell science, 128(9), pp.1848-1861.

85. Koh, D.I., Han, D., Ryu, H., Choi, W.I., Jeon, B.N., Kim, M.K., Kim, Y., Kim, J.Y., Parry, L., Clarke, A.R. and Reynolds, A.B., 2014. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proceedings of the National Academy of Sciences, 111(42), pp.15078-15083.

84. Lee, J., Ryu, H., Keum, G., Yoon, Y.J. and Kowall, N.W., 2014. Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS). Current medicinal chemistry, 21(31), pp.3576-3582.

83. Jo, S., Yarishkin, O., Hwang, Y.J., Chun, Y.E., Park, M., Woo, D.H., Bae, J.Y., Kim, T., Lee, J., Chun, H. and Park, H.J., 2014. GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease. Nature medicine, 20(8), pp.886-896.

82. Lee, J., Hwang, Y.J., Ryu, H., Kowall, N.W. and Ryu, H., 2014. Nucleolar dysfunction in Huntington's disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1842(6), pp.785-790.

81. Park, E., Kim, Y., Ryu, H., Kowall, N.W., Lee, J. and Ryu, H., 2014. Epigenetic mechanisms of Rubinstein–Taybi syndrome. Neuromolecular medicine, 16(1), pp.16-24.

80. Hwang, Y.J., Han, D., Kim, K.Y., Min, S.J., Kowall, N.W., Yang, L., Lee, J., Kim, Y. and Ryu, H., 2014. ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription. Nucleic acids research, 42(3), pp.1628-1643.

79. Kim, K.Y., Hwang, Y.J., Jung, M.K., Choe, J., Kim, Y., Kim, S., Lee, C.J., Ahn, H., Lee, J., Kowall, N.W. and Kim, Y.K., 2014. A multifunctional protein EWS regulates the expression of Drosha and microRNAs. Cell Death & Differentiation, 21(1), pp.136-145.

78. Lee, J., Hwang, Y.J., Kim, K.Y., Kowall, N.W. and Ryu, H., 2013. Epigenetic mechanisms of neurodegeneration in Huntington’s disease. Neurotherapeutics, 10(4), pp.664-676.

77. Lee, J.K., Shin, J.H., Hwang, S.G., Gwag, B.J., McKee, A.C., Lee, J., Kowall, N.W., Ryu, H., Lim, D.S. and Choi, E.J., 2013. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proceedings of the National Academy of Sciences, 110(29), pp.12066-12071.

76. Lee, J., Hwang, Y.J., Shin, J.Y., Lee, W.C., Wie, J., Kim, K.Y., Lee, M.Y., Hwang, D., Ratan, R.R., Pae, A.N. and Kowall, N.W., 2013. Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca 2+ signaling in Huntington’s disease. Acta neuropathologica, 125(5), pp.727-739.

75. Song, H., Boo, J.H., Kim, K.H., Kim, C., Kim, Y.E., Ahn, J.H., Jeon, G.S., Ryu, H., Kang, D.E. and Mook-Jung, I., 2013. Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis. Cell Death & Differentiation, 20(4), pp.639-648.

74. Jung, M.K., Kim, K.Y., Lee, N.Y., Kang, Y.S., Hwang, Y.J., Kim, Y., Sung, J.J., McKee, A., Kowall, N., Lee, J. and Ryu, H., 2013. Expression of taurine transporter (TauT) is modulated by heat shock factor 1 (HSF1) in motor neurons of ALS. Molecular neurobiology, 47(2), pp.699-710.

73. Lee, S.T., Chu, K., Jung, K.H., Kim, J.H., Huh, J.Y., Yoon, H., Park, D.K., Lim, J.Y., Kim, J.M., Jeon, D. and Ryu, H., 2012. miR‐206 regulates brain‐derived neurotrophic factor in Alzheimer disease model. Annals of neurology, 72(2), pp.269-277.

72. Jeon, G.S., Kim, K.Y., Hwang, Y.J., Jung, M.K., An, S., Ouchi, M., Ouchi, T., Kowall, N., Lee, J. and Ryu, H., 2012. Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington’s disease. Molecular neurobiology, 45(3), pp.550-563.

71. Lee, J., Hong, Y.K., Jeon, G.S., Hwang, Y.J., Kim, K.Y., Seong, K.H., Jung, M.K., Picketts, D.J., Kowall, N.W., Cho, K.S. and Ryu, H., 2012. ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. Cell Death & Differentiation, 19(7), pp.1109-1116.

70. Lee, H., Noh, J.Y., Oh, Y., Kim, Y., Chang, J.W., Chung, C.W., Lee, S.T., Kim, M., Ryu, H. and Jung, Y.K., 2012. IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux. Human molecular genetics, 21(1), pp.101-114.

69. Lee, J., Hwang, Y.J., Boo, J.H., Han, D., Kwon, O.K., Todorova, K., Kowall, N.W., Kim, Y. and Ryu, H., 2011. Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease. Cell Death & Differentiation, 18(11), pp.1726-1735.

68. Lee, J., Kosaras, B., Del Signore, S.J., Cormier, K., McKee, A., Ratan, R.R., Kowall, N.W. and Ryu, H., 2011. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice. Acta neuropathologica, 121(4), pp.487-498.

67. Kim, C.H., Leung, A., Huh, Y.H., Yang, E., Kim, D.J., Leblanc, P., Ryu, H., Kim, K., Kim, D.W., Garland, E.M. and Raj, S.R., 2011. Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine β-hydroxylase. Journal of Biological Chemistry, 286(11), pp.9196-9204.

66. Ryu, H., Jeon, G.S., Cashman, N.R., Kowall, N.W. and Lee, J., 2011. Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS. Laboratory Investigation, 91(3), pp.342-352.

65. McConoughey, S.J., Basso, M., Niatsetskaya, Z.V., Sleiman, S.F., Smirnova, N.A., Langley, B.C., Mahishi, L., Cooper, A.J., Antonyak, M.A., Cerione, R.A. and Li, B., 2010. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. EMBO molecular medicine, 2(9), pp.349-370.

64. Hsu, C.H., Chan, D., Greggio, E., Saha, S., Guillily, M.D., Ferree, A., Raghavan, K., Shen, G.C., Segal, L., Ryu, H. and Cookson, M.R., 2010. MKK6 binds and regulates expression of Parkinson’s disease‐related protein LRRK2. Journal of neurochemistry, 112(6), pp.1593-1604.

63. Lee, J.H. and Ryu, H., 2010. Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker?. BMB reports, 43(10), pp.649-655.

62. Lee, J., Boo, J.H. and Ryu, H., 2009. The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?. Advanced drug delivery reviews, 61(14), pp.1316-1323.

61. Lee, J., Ryu, H. and Kowall, N.W., 2009. Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice. Biochemical and biophysical research communications, 387(1), pp.202-206.

60. Lee, J., Ryu, H. and Kowall, N.W., 2009. Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice. Biochemical and biophysical research communications, 384(4), pp.524-529.

59. Lee, J., Kannagi, M., Ferrante, R.J., Kowall, N.W. and Ryu, H., 2009. Activation of Ets‐2 by oxidative stress induces Bcl‐xL expression and accounts for glial survival in amyotrophic lateral sclerosis. The FASEB Journal, 23(6), pp.1739-1749.

58. Liu, M.L., Liu, M.J., Shen, Y.F., Ryu, H., Kim, H.J., Klupsch, K., Downward, J. and Hong, S.T., 2009. Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-β. Journal of cell science, 122(11), pp.1917-1926.

57. Noh, J.Y., Lee, H., Song, S., Kim, N.S., Im, W., Kim, M., Seo, H., Chung, C.W., Chang, J.W., Ferrante, R.J. and Yoo, Y.J., 2009. SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. Journal of Biological Chemistry, 284(17), pp.11318-11325.

56. Lee, J., Hagerty, S., Cormier, K.A., Kim, J., Kung, A.L., Ferrante, R.J. and Ryu, H., 2008. Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation. Human molecular genetics, 17(12), pp.1774-1782.

55. McKee, A.C., Carreras, I., Hossain, L., Ryu, H., Klein, W.L., Oddo, S., LaFerla, F.M., Jenkins, B.G., Kowall, N.W. and Dedeoglu, A., 2008. Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain research, 1207, pp.225-236.

54. Lee, J., Sharma, S., Kim, J., Ferrante, R.J. and Ryu, H., 2008. Mitochondrial nuclear receptors and transcription factors: who's minding the cell?. Journal of neuroscience research, 86(5), pp.961-971.

53. Stack, E.C., Ferro, J.L., Kim, J., Del Signore, S.J., Goodrich, S., Matson, S., Hunt, B.B., Cormier, K., Smith, K., Matson, W.R. and Ryu, H., 2008. Therapeutic attenuation of mitochondrial dysfunction and oxidative stress in neurotoxin models of Parkinson's disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1782(3), pp.151-162.

52. Guan, Y.J., Wang, X., Wang, H.Y., Kawagishi, K., Ryu, H., Huo, C.F., Shimony, E.M., Kristal, B.S., Kuhn, H.G. and Friedlander, R.M., 2007. Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. Journal of neurochemistry, 102(4), pp.1125-1138.

51. Stack, E.C., Del Signore, S.J., Luthi-Carter, R., Soh, B.Y., Goldstein, D.R., Matson, S., Goodrich, S., Markey, A.L., Cormier, K., Hagerty, S.W. and Smith, K., 2007. Modulation of nucleosome dynamics in Huntington's disease. Human molecular genetics, 16(10), pp.1164-1175.

50. Ryu, H. and Ferrante, R.J., 2007. Translational Therapeutic Str ategies in Amyotrophic Lateral Sclerosis. Mini reviews in medicinal chemistry, 7(2), pp.141-150.

49. Ryu, H., Lee, J., Hagerty, S.W., Soh, B.Y., McAlpin, S.E., Cormier, K.A., Smith, K.M. and Ferrante, R.J., 2006. ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proceedings of the National Academy of Sciences, 103(50), pp.19176-19181.

48. Lee, J., Kosaras, B., Aleyasin, H., Han, J.A., Park, D.S., Ratan, R.R., Kowall, N.W., Ferrante, R.J., Lee, S.W., Ryu, H. and Lee, J., 2006. Role of cyclooxygenase‐2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. The FASEB journal, 20(13), pp.2375-2377.

47. Smith, K.M., Matson, S., Matson, W.R., Cormier, K., Del Signore, S.J., Hagerty, S.W., Stack, E.C., Ryu, H. and Ferrante, R.J., 2006. Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1762(6), pp.616-626.

46. Stack, E.C., Smith, K.M., Ryu, H., Cormier, K., Chen, M., Hagerty, S.W., Del Signore, S.J., Cudkowicz, M.E., Friedlander, R.M. and Ferrante, R.J., 2006. Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1762(3), pp.373-380.

45. Ryu, H., Smith, K., Camelo, S.I., Carreras, I., Lee, J., Iglesias, A.H., Dangond, F., Cormier, K.A., Cudkowicz, M.E., H. Brown Jr, R. and Ferrante, R.J., 2005. Sodium phenylbutyrate prolongs survival and regulates expression of anti‐apoptotic genes in transgenic amyotrophic lateral sclerosis mice. Journal of neurochemistry, 93(5), pp.1087-1098.

44. Lee, M.S., Kim, M.K., Ryu, H., Shin, B.C. and Kim, Y.S., 2006. Qi-training and immunological parameters: a cross-sectional study. International journal of neuroscience, 116(8), pp.921-926.

43. Lee, J., Kim, C.H., Simon, D.K., Aminova, L.R., Andreyev, A.Y., Kushnareva, Y.E., Murphy, A.N., Lonze, B.E., Kim, K.S., Ginty, D.D., Ferrante, R.J., Ryu, H. and Ratan, R.R., 2005. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. Journal of Biological Chemistry, 280(49), pp.40398-40401.

42. Ryu, H., Rosas, H.D., Hersch, S.M. and Ferrante, R.J., 2005. The therapeutic role of creatine in Huntington's disease. Pharmacology & therapeutics, 108(2), pp.193-207.

41. Stack, E.C., Kubilus, J.K., Smith, K., Cormier, K., Del Signore, S.J., Guelin, E., Ryu, H., Hersch, S.M. and Ferrante, R.J., 2005. Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice. Journal of Comparative Neurology, 490(4), pp.354-370.

40. Ryu, H., Lee, J., Impey, S., Ratan, R.R. and Ferrante, R.J., 2005. Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons. Proceedings of the National Academy of Sciences, 102(39), pp.13915-13920.

39. Camelo, S., Iglesias, A.H., Hwang, D., Due, B., Ryu, H., Smith, K., Gray, S.G., Imitola, J., Duran, G., Assaf, B. and Langley, B., 2005. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 164(1-2), pp.10-21.

38. Ryu, H., Smith, K., Camelo, S.I., Carreras, I., Lee, J., Iglesias, A.H., Dangond, F., Cormier, K.A., Cudkowicz, M.E., H. Brown Jr, R. and Ferrante, R.J., 2005. Sodium phenylbutyrate prolongs survival and regulates expression of anti‐apoptotic genes in transgenic amyotrophic lateral sclerosis mice. Journal of neurochemistry, 93(5), pp.1087-1098.

37. Krasnikov, B.F., Kim, S.Y., McConoughey, S.J., Ryu, H., Xu, H., Stavrovskaya, I., Iismaa, S.E., Mearns, B.M., Ratan, R.R., Blass, J.P. and Gibson, G.E., 2005. Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria. Biochemistry, 44(21), pp.7830-7843.

36. Ryu, H. and Ferrante, R.J., 2005. Emerging chemotherapeutic strategies for Huntington’s disease. Expert opinion on emerging drugs, 10(2), pp.345-363.

35. Aminova, L.R., Chavez, J.C., Lee, J., Ryu, H., Kung, A., LaManna, J.C. and Ratan, R.R., 2005. Prosurvival and prodeath effects of hypoxia-inducible factor-1α stabilization in a murine hippocampal cell line. Journal of Biological Chemistry, 280(5), pp.3996-4003.

34. Gardian, G., Browne, S.E., Choi, D.K., Klivenyi, P., Gregorio, J., Kubilus, J.K., Ryu, H., Langley, B., Ratan, R.R., Ferrante, R.J. and Beal, M.F., 2005. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. Journal of Biological Chemistry, 280(1), pp.556-563.

33. Lee, M.S., Kim, M.K. and Ryu, H., 2005. Qi-training (qigong) enhanced immune functions: what is the underlying mechanism?. International journal of neuroscience, 115(8), pp.1099-1104.

32. Lee, M.S., Kang, C.W. and Ryu, H., 2005. Acute effect of qi-training on natural killer cell subsets and cytotoxic activity. International journal of neuroscience, 115(2), pp.285-297.

31. Ferrante, R.J., Ryu, H., Kubilus, J.K., D'Mello, S., Sugars, K.L., Lee, J., Lu, P., Smith, K., Browne, S., Beal, M.F. and Kristal, B.S., 2004. Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. Journal of Neuroscience, 24(46), pp.10335-10342.

30. Lee, M.S., Kang, C.W. and Ryu, H., 2004. Effect of qi training on neutrophil function in young and elderly males. Journal of Alternative & Complementary Medicine, 10(4), pp.681-683.

29. Fink, J.S., Kalda, A., Ryu, H., Stack, E.C., Schwarzschild, M.A., Chen, J.F. and Ferrante, R.J., 2004. Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3‐nitropropionic acid‐induced striatal damage. Journal of neurochemistry, 88(3), pp.538-544.

28. Ohtsuka, T., Ryu, H., Minamishima, Y.A., Macip, S., Sagara, J., Nakayama, K.I., Aaronson, S.A. and Lee, S.W., 2004. ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway. Nature cell biology, 6(2), pp.121-128.

27. LEE, M.S. and Ryu, H., 2004. Qi-training enhances neutrophil function by increasing growth hormone levels in elderly men. International journal of neuroscience, 114(10), pp.1313-1322.

26. Lee, M.S., Ryu, H., Song, J. and Moon, S.R., 2004. Brief Communication: EFFECTS OF QI-TRAINING (QIGONG) ON FOREARM BLOOD GAS CONCENTRATIONS. International journal of neuroscience, 114(11), pp.1503-1510.

25. Lee, M.S., Kang, C.W., Ryu, H. and Moon, S.R., 2004. Endocrine and immune effects of qi-training. International journal of neuroscience, 114(4), pp.529-537.

24. Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P.W., Ratan, R.R. and Sen, C.K., 2003. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. Journal of Biological Chemistry, 278(44), pp.43508-43515.

23. Ferrante, R.J., Kubilus, J.K., Lee, J., Ryu, H., Beesen, A., Zucker, B., Smith, K., Kowall, N.W., Ratan, R.R., Luthi-Carter, R. and Hersch, S.M., 2003. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. Journal of Neuroscience, 23(28), pp.9418-9427.

22. Ryu, H., Lee, J., Zaman, K., Kubilis, J., Ferrante, R.J., Ross, B.D., Neve, R. and Ratan, R.R., 2003. Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. Journal of Neuroscience, 23(9), pp.3597-3606.

21. Lee, J., Ryu, H., Ferrante, R.J., Morris, S.M. and Ratan, R.R., 2003. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proceedings of the National Academy of Sciences, 100(8), pp.4843-4848.

20. Ryu, H., Lee, J., Olofsson, B.A., Mwidau, A., Deodoglu, A., Escudero, M., Flemington, E., Azizkhan-Clifford, J., Ferrante, R.J. and Ratan, R.R., 2003. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proceedings of the National Academy of Sciences, 100(7), pp.4281-4286.

19. Ohtsuka, T., Ryu, H., Minamishima, Y.A., Ryo, A. and Lee, S.W., 2003. Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulation. Oncogene, 22(11), pp.1678-1687.

18. Lee, M.S., Jeong, S.M., Jang, H.S., Ryu, H. and Moon, S.R., 2003. Effects of in vitro and in vivo qi-therapy on neutrophil superoxide generation in healthy male subjects. The American journal of Chinese medicine, 31(04), pp.623-628.

17. Lee, M.S., Jeong, S.M., Kim, Y.K., Park, K.W., Lee, M.S., Ryu, H. and Moon, S.R., 2003. Qi-training enhances respiratory burst function and adhesive capacity of neutrophils in young adults: a preliminary study. The American journal of Chinese medicine, 31(01), pp.141-148.

16. Lee, M.S., Huh, H.J., Jeong, S.M., Jang, H.S., Ryu, H., Park, J.H., Chung, H.T. and Woo, W.H., 2003. Effects of Qigong on immune cells. The American journal of Chinese medicine, 31(02), pp.327-335.

15. Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P.W., Ratan, R.R. and Sen, C.K., 2003. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. Journal of Biological Chemistry, 278(44), pp.43508-43515.

14. Ratan, R.R., Semenza, G., Ryu, H., Zaman, K., Aminova, L., Lee, J., Kung, A. and Mwidau, A., 2002. Transcriptional mechanisms of neuroprotection by iron chelators. Journal of Neurochemistry, 81, pp.80-80.

13. Lee, M.S., Huh, H.J., Kim, B.G., Ryu, H., Lee, H.S., Kim, J.M. and Chung, H.T., 2002. Effects of Qi-training on heart rate variability. The American journal of Chinese medicine, 30(04), pp.463-470.

12. Ratan, R.R., Ryu, H., Lee, J., Mwidau, A., and Neve, R.L., 2002. In vitro model of oxidative stress in cortical neurons. Methods in enzymology, 352, pp.183–19

11. Chatterjee, S., Zaman, K., Ryu, H., Conforto, A. and Ratan, R.R., 2001. Sequence‐selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons. Annals of neurology, 49(3), pp.345-354.

10. Lee, M.S., Huh, H.J., Jang, H.S., Han, C.S., Ryu, H. and Chung, H.T., 2001. Effects of emitted Qi on in vitro natural killer cell cytotoxic activity. The American journal of Chinese medicine, 29(01), pp.17-22.

9. Lee, M.S., Yang, K.H., Huh, H.J., Kim, H.W., Ryu, H., Lee, H.S. and Chung, H.T., 2001. Qi therapy as an intervention to reduce chronic pain and to enhance mood in elderly subjects: a pilot study. The American journal of Chinese medicine, 29(02), pp.237-245.

8. Lee, M.S., Huh, H.J., Hong, S.S., Jang, H.S., Ryu, H., Lee, H.S. and Chung, H.T., 2001. Psychoneuroimmunological effects of Qi‐therapy: preliminary study on the changes of level of anxiety, mood, cortisol and melatonin and cellular function of neutrophil and natural killer cells. Stress and Health: Journal of the International Society for the Investigation of Stress, 17(1), pp.17-24.

7. Ryu, H., Lee, J.H., Kim, K.S., Jeong, S.M., Kim, P.H. and Chung, H.T., 2000. Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. The Journal of Immunology, 165(4), pp.2116-2123.

6. Ryu, H., Lee, M.S., Jeong, S.M., Lee, J.H., Kang, C.W., Lee, D.Y. and Chung, H.T., 2000. Modulation of neuroendocrinological function by psychosomatic training: acute effect of ChunDoSunBup Qi-training on growth hormone, insulin-like growth factor (IGF)-I, and insulin-like growth factor binding protein (IGFBP)-3 in men. Psychoneuroendocrinology, 25(5), pp.439-451.

5. Lee, M.S., Kim, B.G., Huh, H.J., Ryu, H., Lee, H.S. and Chung, H.T., 2000. Effect of Qi‐training on blood pressure, heart rate and respiration rate. Clinical Physiology, 20(3), pp.173-176.

4. Lee, M.S., Ryu, H. and Chung, H.T., 2000. Stress management by psychosomatic training: effects of ChunDoSunBup Qi‐training on symptoms of stress: a cross‐sectional study. Stress Medicine, 16(3), pp.161-166.

3. Zaman, K., Ryu, H., Hall, D., O'Donovan, K., Lin, K.I., Miller, M.P., Marquis, J.C., Baraban, J.M., Semenza, G.L. and Ratan, R.R., 1999. Protection from oxidative stress–induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced dna binding of hypoxia-inducible factor-1 and atf-1/creb and increased expression of glycolytic enzymes, p21waf1/cip1, and erythropoietin. Journal of Neuroscience, 19(22), pp.9821-9830.

2. Lee, M.S., Jeong, S.M., Kim, B.G., Ryu, H., Oh, S.W. and Chung, B.T., 1999. A minnesota multiphasic personality inventory profile of chundosunbup Qi-trainees: A preliminary study. The American journal of Chinese medicine, 27(03n04), pp.307-313.

1. Lee, M.S., Kang, C.W., Ryu, H., Kim, J.D. and Chung, H.T., 1999. Effects of ChunDoSunBup Qi-training on growth hormone, insulin-like growth factor-I, and testosterone in young and elderly subjects. The American journal of Chinese medicine, 27(02), pp.167-176.